Evaluation of Response to Weight-based Dosing Strategies of Continuous, Fixed-Rate Atracurium Infusions in Critically Ill, Obese Adults With Acute Respiratory Distress Syndrome
In patients with obesity with ARDS receiving fixed-rate atracurium infusions, the change in P/F at 48 hours did not differ based on weight. Atracurium dosed on IBW may use less total drug without compromising ability to improve oxygenation. This is the first study comparing the dosing weight used for continuous infusion atracurium in hospitalized, critically ill ARDS patients with obesity. Additional studies are warranted to optimize dosing in obese patients.
Authors
- Kaivan Patel (ORCID: https://orcid.org/0000-0002-1976-0849)
- Heather Torbic (ORCID: https://orcid.org/0000-0002-1961-4104)
- Abhijit Duggal (ORCID: https://orcid.org/0000-0003-4220-2359)
- Stephanie Bass (ORCID: https://orcid.org/0000-0001-5175-0459)
- Michael Rudoni (ORCID: https://orcid.org/0000-0001-8101-7645)
- Gretchen L. Sacha (ORCID: https://orcid.org/0000-0002-0070-8100)
- Lu Wang (ORCID: https://orcid.org/0000-0002-6846-8588)
Institutions
- Cleveland Clinic (US)
Publication Details
- Journal
- Annals of Pharmacotherapy
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1177/10600280241304406
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00