A New Dawn for Geriatric Bipolar Disorder: Promising Impact of Endoxifen – A Case Report

Bipolar disorder (BD) is a complex and debilitating mood disorder that affects a significant portion of the population, including the elderly. This case report briefs the utilization of endoxifen for the treatment of BD in an elderly patient. A 74-year-old male with a history of recurrent manic episodes exhibited symptoms of irritability, over-talkativeness, overspending, and disturbed sleep. After unsuccessful attempts with various medications, including mood stabilizers and antipsychotics, the patient was prescribed endoxifen 4 mg daily, escalating to 8 mg within four days. Over six weeks, a remarkable improvement was observed, evident in a decrease in the Young Mania rating scale (YMRS) score from 32 to 6. Notably, minimal side effects were encountered. This case underscores the potential of endoxifen as a promising therapeutic option for managing bipolar disorder in the elderly. Further research with larger cohorts is warranted to validate these findings and explore their long-term efficacy and safety.