The F508del-CFTR trafficking correctors elexacaftor and tezacaftor are CFTR-independent Ca2+-mobilizing agonists normalizing abnormal Ca2+ levels in human airway epithelial cells
We show that ETI not only corrects the abnormal trafficking and function of F508del-CFTR but also normalizes calcium homeostasis in our cellular models. Finally, we identified SERCA as a potential intracellular target for tezacaftor.
Authors
- Manuella Lévêque (ORCID: https://orcid.org/0000-0001-6642-0372)
- Isabelle Fixe
- C. Barrault
- Édouard Sage (ORCID: https://orcid.org/0000-0001-7654-474X)
- Christelle Coraux (ORCID: https://orcid.org/0000-0001-5345-5074)
- Frédéric Becq (ORCID: https://orcid.org/0000-0003-3915-0973)
- Sandra Mirval
- Clarisse Vandebrouck (ORCID: https://orcid.org/0000-0002-9401-0546)
Institutions
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris-Saclay (FR)
- Université de Poitiers (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Virologie et Immunologie Moléculaires (FR)
- Hôpital Foch (FR)
- Pathologies Pulmonaires et Plasticité Cellulaire
- Université de Reims Champagne-Ardenne (FR)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s12931-024-03059-8
- Citations
- 3
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Agence Nationale de la Recherche
- Association Vaincre la Mucoviscidose