High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions
High RF titers in long-standing RA were associated with worse disease activity, lower physical functionality, increased extra-articular manifestations, and higher usage of corticosteroids and bDMARDs. Comparing high vs. non-high RF titers (rather than positive vs. negative RF) seems more useful for evaluating the clinical effects of RF in RA. This approach should be considered in future studies of RF.
Authors
- Geraldo da Rocha Castelar Pinheiro (ORCID: https://orcid.org/0000-0002-7778-569X)
- Ana Paula Monteiro Gomides (ORCID: https://orcid.org/0000-0003-2884-2210)
- Cleandro Pires de Albuquerque (ORCID: https://orcid.org/0000-0002-9245-7504)
- Karina Rossi Bonfiglioli (ORCID: https://orcid.org/0000-0003-3547-5674)
- S. Radominski (ORCID: https://orcid.org/0000-0001-6366-8401)
- Claiton Viegas Brenol (ORCID: https://orcid.org/0000-0003-0229-7912)
- Luı́sa Pereira (ORCID: https://orcid.org/0000-0002-4271-1527)
- Ivânio Alves Pereira (ORCID: https://orcid.org/0000-0002-3910-4988)
- Manoel Barros Bértolo (ORCID: https://orcid.org/0000-0002-0254-4330)
- Vinícius Duarte de Oliveira (ORCID: https://orcid.org/0009-0009-2930-8088)
- Paulo Louzada‐Júnior (ORCID: https://orcid.org/0000-0003-2585-3870)
- Lícia Maria Henrique da Mota (ORCID: https://orcid.org/0000-0002-8182-5121)
- Maria Fernanda Brandão de Resende Guimarães (ORCID: https://orcid.org/0000-0003-3865-3739)
- R. D. Neubarth Giorgi
- Maria de Fátima L.C. Sauma
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade de Ribeirão Preto (BR)
- Universidade de Brasília (BR)
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Universidade do Sul de Santa Catarina (BR)
- Hospital Universitário de Brasília (BR)
- University Center of Brasília (BR)
- Hospital do Servidor Público Estadual (BR)
- Universidade Federal do Pará (BR)
Publication Details
- Journal
- Rheumatology and Therapy
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1007/s40744-024-00730-w
- Citations
- 4
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Amgen
- Eli Lilly and Company
- Pfizer
- UCB Pharma