Exploring the Genetic Landscape of Mycobacterium tuberculosis: Unlocking the Differences in Between Latent and Active Tuberculosis
The newly identified frameshift mutations (fbiC, PPE35, and ald genes), consistently found in both laboratory and clinical isolates, seem to play a critical role in the survival of MTB during dormancy. Based on these findings, designing a molecular test to differentiate between active and latent TB possibly enables timely prophylactic interventions.
Authors
- Ali Akbar Velayati (ORCID: https://orcid.org/0000-0001-9398-5838)
- Poopak Farnia (ORCID: https://orcid.org/0000-0003-3190-2827)
- Jalaledin Ghanavi (ORCID: https://orcid.org/0000-0002-4415-4840)
- Mohsen Maleknia (ORCID: https://orcid.org/0000-0003-4559-6525)
- Yoshiro Murase (ORCID: https://orcid.org/0000-0003-0240-8352)
- Parissa Farnia (ORCID: https://orcid.org/0000-0002-2419-1601)
- Sven Hoffner
- Satoshi Mitaria
Institutions
- Karolinska Institutet (SE)
- Masih Daneshvari Hospital (IR)
- Japan Anti Tuberculosis Association (JP)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- International Journal of Mycobacteriology
- Published
- 2024-10-01
- DOI
- https://doi.org/10.4103/ijmy.ijmy_212_24
- Citations
- 7
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.72