Diagnostic Challenges due to a Germline Missense <scp><i>MSH2</i></scp> Variant in a Patient With Immunotherapy‐Responsive Locally Advanced Rectal Adenocarcinoma
The findings emphasize the utility of an integrative approach in the assessment of MMR status for determining candidacy for immunotherapy, especially in the setting of missense variants in MMR genes.
Authors
- Carla Harmath (ORCID: https://orcid.org/0000-0002-6521-9498)
- Jeremy Segal (ORCID: https://orcid.org/0009-0006-8707-7140)
- Gertruda Evaristo (ORCID: https://orcid.org/0000-0002-6750-9026)
- Ardaman P. Shergill (ORCID: https://orcid.org/0000-0002-8244-2704)
- Namrata Setia (ORCID: https://orcid.org/0000-0002-6060-4717)
Institutions
- University of Chicago (US)
Publication Details
- Journal
- Cancer Reports
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/cnr2.70037
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00