Biological hallmarks of systemic sclerosis are present in the skin and serum of patients with Very Early Diagnosis of Systemic Sclerosis (VEDOSS)
Despite not fulfilling classification criteria, VEDOSS patients show SSc-linked fibrosis and immunity dysregulation both within the tissue and sera, supporting a biological diagnosis of disease and a window of opportunity to detect the biological pathways amenable for preventive intervention.
Authors
- Andrea Rindone
- Christopher W. Wasson (ORCID: https://orcid.org/0000-0001-6558-4738)
- Emily L. Clarke (ORCID: https://orcid.org/0000-0001-7106-9898)
- Panji Mulipa
- Enrico De Lorenzis (ORCID: https://orcid.org/0000-0001-9819-105X)
- Begoña Caballero-Ruiz (ORCID: https://orcid.org/0000-0001-5278-5573)
- Ariane L. Herrick (ORCID: https://orcid.org/0000-0003-4941-7926)
- Francesco Del Galdo (ORCID: https://orcid.org/0000-0002-8528-2283)
- Natalia A. Riobo‐Del Galdo (ORCID: https://orcid.org/0000-0002-8942-7873)
- Stefano Di Donato (ORCID: https://orcid.org/0000-0003-2396-2061)
- Vishal Kakkar (ORCID: https://orcid.org/0000-0003-0513-8677)
- Rebecca L. Ross (ORCID: https://orcid.org/0000-0001-7750-4280)
- Christopher P. Denton (ORCID: https://orcid.org/0000-0003-3975-8938)
- Will Merchant
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Leeds (GB)
- University of Milan (IT)
- Chapel Allerton Hospital (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Manchester Academic Health Science Centre (GB)
- St James's University Hospital (GB)
- Agostino Gemelli University Polyclinic (IT)
- University of Manchester (GB)
- Istituto Ortopedico Gaetano Pini (IT)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
- British Society for Rheumatology (GB)
- University of the Sacred Heart (JP)
- Institute of Structural and Molecular Biology (GB)
- Center for Rheumatology (US)
- University College London (GB)
- Leeds Beckett University (GB)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1093/rheumatology/keae698
- Citations
- 11
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Sight Research UK
- Manchester Biomedical Research Centre
- Medical Research Council
- Leeds Biomedical Research Centre
- Faculty of Medicine and Health, University of Sydney