Ribosomal protein L36-mediated selective loading of microRNA-4432 into extracellular vesicles contributes to perivascular cell dysfunction in venous malformations
This study, for the first time, identified an interaction between VM ECs and PCs via EVs, and offers valuable data on the miRNA profiles of VM ECs and normal ECs, along with their EVs. Our findings suggest that the RPL36-mediated selective loading of miR-4432 into EVs may contribute to the aberrant PC coverage in VMs, providing novel insights into VM pathogenesis and potential treatment strategies.
Authors
- He‐Jing Zhang
- Lin‐Zhou Zhang (ORCID: https://orcid.org/0000-0001-7688-9297)
- Hou-Fu Xia (ORCID: https://orcid.org/0000-0002-8226-5461)
- Kui-Ming Wang (ORCID: https://orcid.org/0000-0003-2660-2280)
- Gao‐Hong Chen
- Gang Chen (ORCID: https://orcid.org/0000-0003-3332-3511)
- Jian‐Gang Ren (ORCID: https://orcid.org/0000-0002-1882-1865)
Institutions
- Wuhan University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1093/bjd/ljae492
- Citations
- 4
- Primary Topic
- Vascular Malformations and Hemangiomas
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities