Prognostic Value of Systemic Immune-Inflammation Index (SII), Platelet-Lymphocyte Ratio (PLR) and Neutrophil-Lymphocyte Ratio (NLR) in Predicting Mortality in Pneumosepsis Patients in Intensive Care Unit

Background: This study aims to evaluate the prognostic value of Systemic Immune-Inflammation Index (SII), Platelet-Lymphocyte Ratio (PLR) and Neutrophil-Lymphocyte Ratio (NLR) to predict mortality in patients with pneumosepsis in the intensive care unit (ICU). Materials and Methods: The study was conducted retrospectively and clinical data of patients diag-nosed with pneumosepsis were analyzed. Age, gender, comorbidities, length of stay (LOS) in the ICU, Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, SII, PLR, NLR values and prognoses were obtained from patient files and hospital records system. Results: A total of 68 patients were included in the study. 60.3% of the patients were male and 39.7% were female. The mean age of deceased patients was statistically significantly higher than that of discharged patients (p = 0.016). In the study, 22 patients were discharged and 46 patients died. While the mean SII value was 464.05±107.31 in the discharged group, this value was 845.53±111.04 in those who died (p<0.001). Similarly, the PLR value was 88.14 ± 10.66 in those discharged and 114.89±12.97 in those who died (p<0.001). The NLR value was 3.5 ± 0.86 in the discharged group and 6.73±0.84 in the deceased group (p<0.001). Conclusions: This study reveals that SII, NLR and PLR indices are important and reliable indicators for predicting mortality in pneumosepsis patients in the ICU.