Increased Salt-Sensitive Blood Pressure in Women vs Men: Is Relative Hyperaldosteronism the Mechanism?
1) Lower Ang II responsiveness in Ang II-targeted organs was observed in men vs women. 2) Similar 24-hour urine ALDO levels in women and men do not support the concept that relative hyper-ALDO is the mechanism for sex difference in SSBP. The data also suggest that the SSBP in women, in some cases, may be benign since it is secondary to a BP reduction on the restricted-salt diet, not an increase on the liberal-salt diet.
Authors
- José R. Romero (ORCID: https://orcid.org/0000-0001-8225-0772)
- Jonathan S. Williams (ORCID: https://orcid.org/0000-0001-7152-765X)
- Mahyar Heydarpour (ORCID: https://orcid.org/0000-0002-5741-367X)
- Ellen W. Seely (ORCID: https://orcid.org/0000-0002-4425-1878)
- Gordon H. Williams (ORCID: https://orcid.org/0000-0002-4804-1093)
- Gail K. Adler (ORCID: https://orcid.org/0000-0003-3506-7347)
- Luminita H. Pojoga (ORCID: https://orcid.org/0000-0002-9448-6333)
- Kelly Yin Han Wong (ORCID: https://orcid.org/0000-0002-4256-6737)
- Ezgi Caliskan Guzelce (ORCID: https://orcid.org/0000-0002-9574-8032)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1210/clinem/dgae871
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.36
Funders
- Charles A. King Trust
- National Institutes of Health