Formulation And In-Vitro Evaluation of a Ketoconazole Microsponge Drug Delivery System for Enhanced Antifungal

This study focused on the synthesis and characterization of Ketoconazole microsponges using the quasi-emulsion solvent diffusion method, followed by a comprehensive evaluation of their properties and performance. The microsponges demonstrated high production yield, loading efficiency, and desirable particle size, with spectral analysis confirming characteristic drug peaks. Scanning Electron Microscopy (SEM) revealed distinct structural differences between styrene and Eudragit-based microsponges. Pore characterization indicated variation in pore types and porosity between the two formulations. Stability studies showed no significant morphological or drug release changes over six months of accelerated storage. Gel formulations incorporating microsponges exhibited enhanced viscosity and controlled drug release compared to gels containing the free drug alone. Antifungal assays indicated that microsponge-loaded gels maintained or improved efficacy relative to free drug gels and commercial formulations, along with reduced skin irritation. These findings highlight the potential of microsponge delivery systems for the topical administration of Ketoconazole, offering controlled release, reduced irritation, and potentially enhanced therapeutic outcomes.