Implementation of Universal Germline Genetic Testing Into Standard of Care for Patients With Prostate Cancer: The Time Is Now
Indications for and implications of germline genetic testing (GGT) in patients with prostate cancer have expanded over the past decade, particularly related to precision therapies and management. GGT has become the standard of care for many cancers such as breast, ovarian, colorectal, pancreatic, and metastatic prostate cancer, and it is imperative that patients be offered timely and equitable access to testing as it can inform patient-physician shared decision making for management of the current cancer as well as anticipatory guidance for disease progression. Additionally, GGT guides screening for and prevention of secondary malignancies for the patient and cascade testing for at-risk family members. Here, we present data supporting the notion that clinicians should offer all patients with prostate cancer the opportunity to undergo comprehensive GGT for pathogenic germline variants known to be associated with familial cancer and/or known to have implications for treatment and management.
Authors
- Elisabeth I. Heath (ORCID: https://orcid.org/0000-0003-1381-2713)
- Edward D. Esplin (ORCID: https://orcid.org/0000-0001-9205-3756)
- Michael J. Morris (ORCID: https://orcid.org/0000-0002-9454-0096)
- Daniel J. George (ORCID: https://orcid.org/0000-0003-1499-7203)
- E. David Crawford (ORCID: https://orcid.org/0000-0002-5009-1655)
- Paul Sieber (ORCID: https://orcid.org/0000-0002-6064-9683)
- Alan Haruo Bryce (ORCID: https://orcid.org/0000-0002-0206-3895)
- Sarah M. Nielsen (ORCID: https://orcid.org/0000-0002-5916-6393)
- Andrew J. Armstrong (ORCID: https://orcid.org/0000-0001-7012-1754)
- Ashley E. Ross (ORCID: https://orcid.org/0000-0001-7044-9688)
- Maha Hussain (ORCID: https://orcid.org/0000-0003-0380-9465)
- Himisha Beltran (ORCID: https://orcid.org/0000-0003-3259-2226)
- Tomasz M. Beer (ORCID: https://orcid.org/0000-0001-5600-9993)
- Michael S. Cookson (ORCID: https://orcid.org/0000-0001-8678-0551)
- Pedro Coelho Barata (ORCID: https://orcid.org/0000-0002-8890-2951)
- Rana R. McKay (ORCID: https://orcid.org/0000-0002-0581-7963)
- Matthew Ryan Smith (ORCID: https://orcid.org/0000-0002-8889-3477)
- Alicia Katherine Morgans (ORCID: https://orcid.org/0000-0002-6563-4587)
- Oliver A. Sartor (ORCID: https://orcid.org/0000-0002-8777-7343)
- David R. Wise (ORCID: https://orcid.org/0000-0003-3419-4723)
- Channing Judith Paller (ORCID: https://orcid.org/0000-0003-3658-1858)
- Neal D. Shore (ORCID: https://orcid.org/0000-0001-5767-0548)
- Tanya Barauskas Dorff (ORCID: https://orcid.org/0000-0001-5990-298X)
- John Shen (ORCID: https://orcid.org/0000-0002-6455-5553)
- Brian T. Helfand (ORCID: https://orcid.org/0000-0002-7707-3318)
- Emmanuel S. Antonarakis (ORCID: https://orcid.org/0000-0003-0031-9655)
Institutions
- University of Minnesota (US)
- Memorial Sloan Kettering Cancer Center (US)
- NorthShore University HealthSystem (US)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- LabCorp (United States) (US)
- University of California San Diego (US)
- NYU Langone Health (US)
- Massachusetts General Hospital (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Exact Sciences (United States) (US)
- City of Hope (US)
- Dana-Farber Cancer Institute (US)
- Mayo Clinic in Arizona (US)
- Duke Medical Center (US)
- Goodyear (United States) (US)
- Dermatology Specialists (US)
- Invitae (United States) (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Carolina Urologic Research Center (US)
- Case Western Reserve University (US)
- University of Oklahoma (US)
Publication Details
- Journal
- JCO Oncology Practice
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1200/op-24-00626
- Citations
- 5
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- Invitae