Proteomic analysis for busulfan-induced spermatogenesis disorder

We revealed 190 significantly downregulated proteins in busulfan-treated mouse testes at 30 days and indicated that 70 days is the cut-off point of spermatogenic recovery for busulfan-treated mouse testis, increasing our understanding of this reproductive disorder model. An increased understanding of busulfan's toxic effect will help to prevent and treat reproductive diseases.

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Publication Details

Journal
Annals of Medicine
Published
2024-12-19
DOI
https://doi.org/10.1080/07853890.2024.2442534
Citations
4
Primary Topic
Endoplasmic Reticulum Stress and Disease
Type
article
Field-Weighted Citation Impact
1.30

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article

Proteomic analysis for busulfan-induced spermatogenesis disorder

S. Yang, Sixieyang Chen, Jiaqi Zou, Jing Yang et al.
4 citations
Annals of Medicine
Endoplasmic Reticulum Stress and Disease
1.30
article

Proteomic analysis for busulfan-induced spermatogenesis disorder

S. Yang, Sixieyang Chen, Jiaqi Zou, Jing Yang, Meng Liang, Xin Li, Fan Li, Min Ye, Biao Ding, Chuanwang Song, Qinran Zhu, Ke Hu
article en
4 citations

Abstract

We revealed 190 significantly downregulated proteins in busulfan-treated mouse testes at 30 days and indicated that 70 days is the cut-off point of spermatogenic recovery for busulfan-treated mouse testis, increasing our understanding of this reproductive disorder model. An increased understanding of busulfan's toxic effect will help to prevent and treat reproductive diseases.

Annals of MedicineVol. 57(1)
Bengbu Medical College (CN), First Affiliated Hospital of Bengbu Medical College (CN)
Bengbu Medical College
Zero hunger
Openalex Percentile: Top 20%
Endoplasmic Reticulum Stress and Disease
1.30
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