A case of opsoclonus-myoclonus syndrome associated with breast cancer
Opsoclonus-myoclonus syndrome (OMS) is a rare presenting complication of cancer that is thought to be related to autoimmune mediated perturbation of homeostasis of oculomotor and limb movement. Symptoms can include arrhythmic conjugate saccades of the eyes without interval and involuntary movements of the limbs. The patient was a 56-year-old woman with OMS and an occult axillary cT0N1M0 triple negative breast cancer (TNBC). She had negative serum and CSF serology. She was initially treated with steroids and immune globulin and then neoadjuvant chemotherapy. She underwent surgical excision and radiation. At 9 years the patient is without recurrence of OMS or TNBC.
Authors
- Bruce Trautman
- Todd M. Tuttle (ORCID: https://orcid.org/0000-0001-6603-2062)
- Sebastián Mohar
- Naomi Fujioka (ORCID: https://orcid.org/0000-0003-3277-6754)
- Jianling Yuan (ORCID: https://orcid.org/0000-0003-1294-3391)
- Emilian Racila (ORCID: https://orcid.org/0000-0002-6474-9649)
- David A. Potter (ORCID: https://orcid.org/0000-0002-4754-9127)
- Sean Joseph Pittock (ORCID: https://orcid.org/0000-0002-6140-5584)
Institutions
- University of Minnesota (US)
- Mayo Clinic in Arizona (US)
- Instituto Nacional de Cancerología (MX)
Publication Details
- Journal
- Current Problems in Cancer Case Reports
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.cpccr.2024.100346
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México
- DOD Peer Reviewed Cancer Research Program