Cannabidiol alleviates <scp>LPS</scp>‐inhibited odonto/osteogenic differentiation in human dental pulp stem cells in vitro
CBD recovers the proliferation and survival of hDPSCs following exposure to LPS. Additionally, we report that CBD-mediated Notch activation effectively restores the odonto/osteogenic differentiation ability of hDPSCs under inflamed conditions. These results underscore the potential role of CBD as a therapeutic option to enhance dentine regeneration.
Authors
- Ajjima Chansaenroj (ORCID: https://orcid.org/0000-0001-8266-7455)
- Ravipha Suwittayarak (ORCID: https://orcid.org/0000-0003-1583-2371)
- Chatvadee Kornsuthisopon (ORCID: https://orcid.org/0000-0002-4656-8158)
- Suphalak Phothichailert (ORCID: https://orcid.org/0009-0001-1581-634X)
- Sornkanok Vimolmangkang (ORCID: https://orcid.org/0000-0002-1705-6217)
- Thanaphum Noom Osathanon (ORCID: https://orcid.org/0000-0003-1649-6357)
- Lakshman P. Samaranayake
- Chaloemrit Phrueksotsai
- Khunakon Usarprom
- Apicha Srikacha
Institutions
- Chulalongkorn University (TH)
- University of Hong Kong (HK)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1111/iej.14183
- Citations
- 5
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 2.24
Funders
- Chulalongkorn University