Altered circadian rhythmicity of the QT interval predicts mortality in a large real-world academic hospital population
Using heterogeneous, real-world hospital data of more than 100,000 patients, circadian rhythmicity proved to be an independent determinant of the QT interval. Both increased and diminished QT rhythmicity was shown to be a predictor of all-cause mortality. QT interval should be corrected for the time-of-day and altered circadian rhythmicity should trigger awareness of increased mortality risk (https://qt.ecgx.ai).
Authors
- René van Es (ORCID: https://orcid.org/0000-0001-9950-4388)
- Linda W. van Laake (ORCID: https://orcid.org/0000-0002-5027-0661)
- Rutger R van de Leur (ORCID: https://orcid.org/0000-0002-4779-5870)
- Markella I Printezi (ORCID: https://orcid.org/0000-0001-6265-6230)
- Rutger J. Hassink (ORCID: https://orcid.org/0000-0003-0237-7867)
- Pieter A. Doevendans (ORCID: https://orcid.org/0000-0002-6257-7169)
- Bastiaan C. du Pré
Institutions
- Utrecht University (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Central Military Hospital (NL)
- Netherlands Heart Institute (NL)
Publication Details
- Journal
- Heliyon
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e41308
- Citations
- 1
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- ZonMw