Hypertension may lead to cognitive dysfunction in older adults via methylmalonic acid: evidence from NHANES 2011–2014 population
Hypertension may lead to cognitive dysfunction in older adults through MMA. Apart from its role as a biomarker reflecting vitamin B12, MMA may act as an independent neurotoxin capable of inducing brain injury and cognitive impairment. Addressing MMA accumulation, such as through Vitamin B12 supplementation, may have a potential to mitigate hypertension-induced cognitive decline in older adults. Special attention could be paid to hypertensive males with an advanced age (> = 68) to address MMA-related cognitive decline.
Authors
- Paulus Torkki (ORCID: https://orcid.org/0000-0002-1127-4205)
- Wei‐Jun Zheng (ORCID: https://orcid.org/0000-0002-9136-2693)
- Rucheng Chen
- An Chen (ORCID: https://orcid.org/0000-0001-9419-8254)
- Ying Xu (ORCID: https://orcid.org/0009-0003-3466-0488)
Institutions
- Zhejiang Chinese Medical University (CN)
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
Publication Details
- Journal
- BMC Geriatrics
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s12877-024-05599-6
- Citations
- 7
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- Zhejiang Chinese Medical University