Bacterial intragenic inversions: a new layer of diversity
DNA inversions in bacteria were known to create diversity through intergenic or partial intergenic changes. Now, Chanin, West, et al. reveal intragenic inversions, enabling single genes to encode multiple protein variants via sequence recoding or truncation - an unexpected mechanism for expanding protein diversity without increasing genome size.
Authors
- Xiaofang Jiang (ORCID: https://orcid.org/0000-0002-0955-8284)
- Brantley Hall (ORCID: https://orcid.org/0000-0001-7553-8209)
Institutions
- United States National Library of Medicine (US)
- University of Maryland, College Park (US)
Publication Details
- Journal
- Trends in Genetics
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.tig.2024.12.002
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- National Institute of General Medical Sciences