Rhodium(III)-Catalyzed Sequential Cyclization of Enaminones with 1,3-Dienes via C–H Activation for the Synthesis of Fluorenones
An efficient method for construction of various fluorenones has been achieved via Rh(III)-catalyzed C-H activation/[4 + 2] annulation/aromatization sequences of simple and readily available enaminones and 1,3-dienes. This protocol showed good substrate compatibility as an array of structurally and electronically diverse fluorenones prepared efficiently in moderate to good yields and preparative scale utility showing very good efficiency in the late-stage functionalization of complex valuable molecules.
Authors
- Maozhong Miao (ORCID: https://orcid.org/0000-0001-6777-7189)
- Jinzhong Yao (ORCID: https://orcid.org/0000-0003-2444-7731)
- Hongwei Zhou (ORCID: https://orcid.org/0000-0001-8308-960X)
- Min Wang (ORCID: https://orcid.org/0000-0002-8776-1560)
- Lei Gao (ORCID: https://orcid.org/0000-0001-8555-5168)
- Hongwei Ren
Institutions
- Zhejiang Sci-Tech University (CN)
- Jiaxing University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1021/acs.joc.4c01956
- Citations
- 8
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- National Natural Science Foundation of China
- Department of Education of Zhejiang Province
- Jiaxing University
- Natural Science Foundation of Zhejiang Province