Hepatic IR and IGF1R signaling govern distinct metabolic and carcinogenic processes upon PTEN deficiency in the liver
This study underscores the pivotal roles of phosphatase and tensin homolog (PTEN), insulin receptor (IR), and IGF-1 receptor (IGF1R) in controlling liver metabolism, systemic adiposity, and liver cancer progression. Our findings on the distinct and combined effects of these receptors in PTEN-deficient mice offer key insights into the mechanisms driving metabolic dysfunction-associated steatotic liver disease and related hepatocarcinogenesis. In addition, this research reveals the potential of IR and IGF1R as biomarkers in liver cancer development, presenting new opportunities for therapeutic targeting and disease monitoring.
Authors
- Monika Gjorgjieva (ORCID: https://orcid.org/0000-0001-8553-7525)
- Etienne Delangre (ORCID: https://orcid.org/0000-0003-1804-5680)
- Nicolas Calo (ORCID: https://orcid.org/0000-0002-0897-4091)
- Michelangelo Foti (ORCID: https://orcid.org/0000-0001-7199-4135)
- Christine Maeder
- Margot Fournier (ORCID: https://orcid.org/0000-0001-8906-1907)
- Flavien Berthou (ORCID: https://orcid.org/0000-0002-2915-1211)
- Cyril Sobolewski (ORCID: https://orcid.org/0000-0002-9404-6290)
- Christine Sempoux (ORCID: https://orcid.org/0000-0003-1375-3979)
- Serge Nef (ORCID: https://orcid.org/0000-0001-5462-0676)
- Dorothea Portius (ORCID: https://orcid.org/0000-0003-2608-1091)
- Marion Peyrou (ORCID: https://orcid.org/0000-0002-1210-6094)
- Jean-Luc Pitetti
- Marta Correia de Sousa (ORCID: https://orcid.org/0009-0008-4175-8551)
- Xavier Montet (ORCID: https://orcid.org/0000-0003-2442-5866)
- Lucie Bourgoin
- Laurent Vinet
- Anne‐Sophie Ay
Institutions
- University of Geneva (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101305
- Citations
- 6
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung