Asymmetric Total Synthesis of (+)-Hyperbeanol A
A bioinspired alkylation dearomatization reaction was developed to construct the 5/6/6 fused-spiro tricyclic core framework and spiro-quaternary carbon chiral center. The usage of this approach for assembling these natural products of spirocyclic polycyclic polyprenylated acylphloroglucinols with an octahydrospiro-[cyclohexan-1,5'-indene] core is demonstrated by the first asymmetric total synthesis of highly oxidized hyperbeanol A.
Authors
- Xingchao Guan
- Zhixiang Xie (ORCID: https://orcid.org/0000-0001-5809-3084)
- Haodong Wang (ORCID: https://orcid.org/0000-0002-2344-2456)
- Wanqiao Zhang (ORCID: https://orcid.org/0000-0001-8654-4313)
Institutions
- Lanzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1021/acs.orglett.4c02930
- Citations
- 2
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- National Natural Science Foundation of China
- Science and Technology Program of Gansu Province