Dissecting the Kaiso binding profile in clear renal cancer cells
The present study delineates the genomic distribution of Kaiso in cancer cells, confirming its role as a factor with a complex mode of DNA binding and a strong association with CpG islands, particularly with methylated and eroded CpG islands, revealing a new potential Kaiso target gene-SQSTM1, involved in differentiation of acute myeloid leukemia cells. Furthermore, we discovered the existence of a new class of CpG islands characterized by wave-like DNA methylation.
Authors
- Pavel M. Abramov (ORCID: https://orcid.org/0000-0002-7995-3490)
- Alexey Starshin (ORCID: https://orcid.org/0000-0002-4965-0165)
- I. E. Deyev (ORCID: https://orcid.org/0000-0002-2041-808X)
- Daria Kaplun (ORCID: https://orcid.org/0000-0002-6370-2208)
- Svetlana Zhenilo (ORCID: https://orcid.org/0000-0003-0874-1594)
- Dmitry N. Kaluzhny (ORCID: https://orcid.org/0000-0001-7090-3334)
- Fedor Sharko (ORCID: https://orcid.org/0000-0002-1189-5597)
- Yaroslava Lobanova (ORCID: https://orcid.org/0009-0002-5919-8499)
- Galina Filonova (ORCID: https://orcid.org/0000-0003-0228-8346)
- Egor Prokhortchou
- Alexander M. Mazur
Institutions
- Engelhardt Institute of Molecular Biology (RU)
- Institute of Bioorganic Chemistry (RU)
- Institute of Gene Biology (RU)
- Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences (RU)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s13072-024-00565-3
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Russian Science Foundation
- Ministry of Science and Higher Education of the Russian Federation
- National Research Center "Kurchatov Institute"