Clinical value of the <i>MGMT</i> promoter methylation score in IDHmt low-grade glioma for predicting benefit from temozolomide treatment
While the <i>MGMTp</i> methylation score was associated with better outcomes in TMZ-treated IDHmt LGG, a cutoff could not be established to guide treatment decisions.
Authors
- Karine Lefort (ORCID: https://orcid.org/0000-0003-0442-2772)
- Amélie Darlix (ORCID: https://orcid.org/0000-0003-1384-1709)
- Emmanuelle Le Bars (ORCID: https://orcid.org/0000-0002-3927-9868)
- Arthur Coget (ORCID: https://orcid.org/0000-0001-9248-7327)
- Tomasz Matys (ORCID: https://orcid.org/0000-0003-2285-5715)
- Mathilde Carrière
- Monika E. Hegi (ORCID: https://orcid.org/0000-0003-0855-6495)
- Valérie Rigau (ORCID: https://orcid.org/0000-0002-8017-5489)
- Jérémy Deverdun (ORCID: https://orcid.org/0000-0002-7083-2940)
- Thomas Santarius (ORCID: https://orcid.org/0000-0002-1416-9566)
- Pierre Bady (ORCID: https://orcid.org/0000-0003-1398-4689)
- Hugues Duffau (ORCID: https://orcid.org/0000-0002-6558-2342)
Institutions
- SIB Swiss Institute of Bioinformatics (CH)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- University Medical Center (US)
- University Hospital and Clinics (US)
- Hôpital Gui de Chauliac (FR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Institut de Génomique Fonctionnelle (FR)
- University of Lausanne (CH)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1093/noajnl/vdae224
- Citations
- 3
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- National Science Foundation
- National Institute for Health and Care Research
- University of Cambridge
- Institut National de la Santé et de la Recherche Médicale
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Brain Tumour Charity
- Cambridge University Hospitals
- Centre National de la Recherche Scientifique
- Université de Lausanne
- Centre Hospitalier Universitaire Vaudois
- Université de Montpellier
- Swiss Cancer Research Foundation
- Swiss Institute of Bioinformatics
- NIHR Cambridge Biomedical Research Centre