Identification of Potential Drug Targets for the Treatment of Severe Burn Wounds from a Multi-Omics Perspective
This study innovatively integrates multi-omics approaches into burn wound research, uncovering for the first time that mevastatin promotes burn wound healing by downregulating CYP19A1 expression. This discovery may provide a new foundation for developing burn wound therapeutics and potentially reduce drug development costs.
Authors
- Jiamin Xu (ORCID: https://orcid.org/0000-0002-4090-7024)
- Jiaqi Li (ORCID: https://orcid.org/0009-0006-3489-1608)
- Guanghua Guo
- Gehua Zhu (ORCID: https://orcid.org/0009-0001-0380-3525)
- Feng Zhu (ORCID: https://orcid.org/0000-0002-4330-0789)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Shanghai East Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s496429
- Citations
- 1
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.25