A Novel Label-Free Method for Efficient Detection of Bisphosphonate Drug Dissolution Rates Using Surface-Enhanced Raman Spectroscopy

We developed a novel method utilizing surface-enhanced Raman spectroscopy (SERS) with calcium ion-modified silver nanoparticles as the enhancing substrate. This approach enables label-free detection of the dissolution rate of bisphosphonates. This technique is fast, sensitive, and highly reproducible, significantly advancing drug quality control. Experimental results demonstrated detection limits for etidronate, alendronate, and risedronate as low as 1 ng/mL. Notably, this method accurately identifies characteristic drug peaks without interference from excipients, allowing for precise quantitative detection. In summary, our SERS-based method offers a simple, efficient, and reliable approach for the qualitative and quantitative quality control of bisphosphonate drugs.

Authors

Institutions

Publication Details

Journal
Analytical Chemistry
Published
2024-12-18
DOI
https://doi.org/10.1021/acs.analchem.4c05136
Citations
2
Primary Topic
Bone health and treatments
Type
article
Field-Weighted Citation Impact
0.57

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

A Novel Label-Free Method for Efficient Detection of Bisphosphonate Drug Dissolution Rates Using Surface-Enhanced Raman Spectroscopy

Junting Wang, Chunli Gan, Yang Li, Shuang Jiang et al.
2 citations
Analytical Chemistry
Bone health and treatments
0.57
article

A Novel Label-Free Method for Efficient Detection of Bisphosphonate Drug Dissolution Rates Using Surface-Enhanced Raman Spectroscopy

Junting Wang, Chunli Gan, Yang Li, Shuang Jiang, Chunjuan Yang, Xiaotong Wang, Zhibin Wang, Yue Zhao, Zheng Feng, Huimin Yu, Yuanqiu Mu, Li Zhang
article en
2 citations

Abstract

We developed a novel method utilizing surface-enhanced Raman spectroscopy (SERS) with calcium ion-modified silver nanoparticles as the enhancing substrate. This approach enables label-free detection of the dissolution rate of bisphosphonates. This technique is fast, sensitive, and highly reproducible, significantly advancing drug quality control. Experimental results demonstrated detection limits for etidronate, alendronate, and risedronate as low as 1 ng/mL. Notably, this method accurately identifies characteristic drug peaks without interference from excipients, allowing for precise quantitative detection. In summary, our SERS-based method offers a simple, efficient, and reliable approach for the qualitative and quantitative quality control of bisphosphonate drugs.

Analytical ChemistryVol. 96(52)
Harbin Medical University (CN), Heilongjiang University of Chinese Medicine (CN), Harvard–MIT Division of Health Sciences and Technology (US), Shanghai Institute of Materia Medica (CN), First Affiliated Hospital of Guangdong Pharmaceutical University (CN), Fourth Affiliated Hospital of Harbin Medical University (CN), First Affiliated Hospital of Chinese PLA General Hospital (CN), Second Affiliated Hospital of Harbin Medical University (CN), Innovative Research (United States) (US), First Affiliated Hospital of Harbin Medical University (CN), University of Oulu (FI)
National Natural Science Foundation of China
Openalex Percentile: Top 26%
Bone health and treatments
0.57
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.