Assessing the impact of CD73 inhibition on overcoming anti-EGFR resistance in glioma cells
In summary, our findings indicate that CD73 inhibition has a modest effect in overcoming resistance to EGFR monotherapy <i>in vitro</i>. Thus, further <i>in vivo</i> studies are needed, as the inhibition of both EGFR and CD73 affects cells in the tumor microenvironment and could potentially enhance anti-tumor immunity.
Authors
- Jean Sévigny (ORCID: https://orcid.org/0000-0003-2922-1600)
- Juliete Nathali Scholl (ORCID: https://orcid.org/0000-0002-9509-2010)
- Luiz Fernando Lopes Silva (ORCID: https://orcid.org/0000-0002-7627-3967)
- Ana Maria Battastini
- Pauline Rafaela Pizzato
- Camila Kehl Dias (ORCID: https://orcid.org/0000-0002-1898-1420)
- Fabrício Figueiró (ORCID: https://orcid.org/0000-0003-0899-6407)
- Vinícius Pierdoná Lima (ORCID: https://orcid.org/0000-0001-5072-9789)
- Augusto Ferreira Weber (ORCID: https://orcid.org/0000-0002-1712-5366)
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2024-12-19
- DOI
- https://doi.org/10.32604/or.2024.055508
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00