Enhancing HBV-specific T cell responses through a combination of epigenetic modulation and immune checkpoint inhibition
The combination of DAC/αPD-L1 shows promise in improving HBV-specific T cell responses in vitro , highlighting the potential of remodeling exhaustion-associated epigenetic signatures to enhance HBV-specific T cell restoration and suggesting a novel immunotherapeutic avenue for chronic HBV infection.
Authors
- Melanie Urbanek‐Quaing (ORCID: https://orcid.org/0000-0002-3629-9011)
- Markus Cornberg (ORCID: https://orcid.org/0000-0002-9141-8001)
- Birgit Bremer (ORCID: https://orcid.org/0000-0002-1239-6968)
- Katja Steppich
- Benjamin Maasoumy (ORCID: https://orcid.org/0000-0002-3250-3177)
- Cheng‐Jian Xu (ORCID: https://orcid.org/0000-0003-1586-4672)
- Heiner H. Wedemeyer (ORCID: https://orcid.org/0000-0003-2906-0480)
- Anke Kraft (ORCID: https://orcid.org/0000-0002-9666-0753)
- Katja Deterding
- Manoj Kumar Gupta (ORCID: https://orcid.org/0000-0002-1432-9793)
- Hagen Schmaus
- Yin-Han Chou
Institutions
- Medizinische Hochschule Hannover (DE)
- German Center for Infection Research (DE)
- Helmholtz Centre for Infection Research (DE)
- Centre for Individualised Infection Medicine (DE)
- Center for Experimental and Clinical Infection Research (DE)
Publication Details
- Journal
- Hepatology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1097/hep.0000000000001202
- Citations
- 9
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.10