Structural Changes in the Kidneys of Rats with Different Adrenoreactivity in Modeled Unilateral Ureteral Obstruction

The dependence of adaptive and compensatory reactions of the kidneys on the sensitivity of β2-adrenoreceptors was studied in a rat model of unilateral ureteral obstruction. The kidney morphology was examined after 24, 48, and 72 hours of obstruction or 30 days after its termination in rats with different adrenoreactivity. In hyperreactive rats, destruction of the tubules, reduced proportion of blood vessels, and leukocyte infiltration of the interstitium were predominant. However, vacuole dystrophy of the tubular epithelium and hemostasis in the medullary vessels prevailed in hyporeactive rats. Following 30 days after 72 h of obstruction, changes in the kidneys of hyper- and hyporeactive rats were more distinct than in normoreactive ones. Thus, the response of the kidneys to ureteral obstruction depends on the β2-adrenoreceptor sensitivity. Importantly both increased and decreased adrenoreactivity deteriorates the recovery.