Evaluation of the Effect of Ethyl Carbamate on CD21+-Spleen Cells

The spleen is an organ of the immune system that is involved in the B-cell immune response. In certain areas of the spleen, naive and mature B lymphocytes are localized. Upon a decrease in B cells in the bloodstream, the spleen replenishes their number. In this organ, antibodies are formed, which are an important link in the humoral immune response. The conducted experiment revealed that a single administration of ethyl carbamate causes changes in both the lungs and the spleen. An analysis of histological sections showed that, six months after the receipt of ethyl carbamate, the spleen showed signs of white pulp involution, along with a decrease in the number of CD21+ cells. This indicates an inhibition of the B-cell immune response and a probable decrease in the humoral immune response.