Case Report: Retransplantation Due to Hepatocellular Carcinoma After Direct Antiviral Agents in Cirrhotic Patients

Introduction . Direct antiviral agents had opened new opportunities of treatment for chronic hepatitis C (HCV) in patients with cirrhosis. However, patients with decompensated liver cirrhosis need special attention and individual approach before antiviral therapy prescription. The aim of the study — to demonstrate a clinical case probability of developing liver cirrhosis complications aſter effective antiviral therapy. Materials and methods . Analysis of medical records of 52 уears old male with HCV-associated liver cirrhosis who was treated with direct antiviral agents with achieving of sustained virologic response (SVR). During follow up hepatocellular carcinoma (HCC) was detected. Patient underwent a liver transplantation complicated by primary non function liver graſt in the early postoperative period. Liver retransplantation with necessity of extracorporeal treatment methods and complex immunosuppressive therapy. Discussion . Antiviral treatment of patients with decompensated liver cirrhosis does not always improve prognosis and sustained SVR does not exclude risk of HCC appearance. Conclusion . Treated patients should be included in monitoring and HCC surveillance program.