Small-Cell Lung Carcinoma in an 8-Year-Old Boy: A Rare Case Report with Review of Literature

Abstract Lung cancer typically affects older adults, with occurrences in children being extremely rare. In adolescents, metastatic lung disease is more common than primary lung cancers. The pathological spectrum of lung cancer in children varies, with small-cell carcinoma being a rare type, accounting for around 4.5% of cases. An 8-year-old boy, previously healthy, presented with moderate-intensity, short-duration chest pain on the left side. Histomorphology, immunohistochemistry characteristics, and fluorescence in situ hybridization confirmed the diagnosis of extensive-stage small-cell lung carcinoma (SCLC). The patient responded positively to six cycles of chemotherapy with etoposide and carboplatin, resulting in the resolution of symptoms. This case underscores the rare instance of SCLC in the pediatric population, emphasizing the diagnostic challenges due to nonspecific symptoms and the necessity for aggressive treatment. It highlights the importance of adapting adult SCLC treatment protocols for pediatric patients to enhance prognosis, given the limited specific guidelines available.