Verbal paired associates learning lateralizes left hippocampal sclerosis in temporal lobe epilepsy
The results of the study show that the ability to learn unrelated pairs of words (e.g., "silver"-"run") is compromised in the setting of epilepsy with left-sided hippocampal sclerosis (HS), be it unilateral left HS or bilateral HS. The ability of unrelated word pair learning to discriminate left vs. right HS was comparable to word list learning, a task with demonstrated sensitivity to left HS. Our results suggest that the ability to learn unrelated pairs of words provides another useful marker of left-sided hippocampal compromise in epilepsy. We provide cutoff scores to facilitate clinical interpretation.
Authors
- David L. Weintrob
- Piero Perucca (ORCID: https://orcid.org/0000-0002-7855-7066)
- Chris Tailby (ORCID: https://orcid.org/0000-0002-1320-5924)
- Marie O’Shea
- Graeme D. Jackson (ORCID: https://orcid.org/0000-0002-7917-5326)
- Angela R. Jackman (ORCID: https://orcid.org/0000-0002-1784-9700)
- John E. Anderson (ORCID: https://orcid.org/0000-0002-2588-6122)
- Andy Sitoh
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Monash Health (AU)
- Alfred Health (AU)
- Austin Health (AU)
- Monash University (AU)
- Australian Psychological Society (AU)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1002/epi4.13118
- Citations
- 4
- Primary Topic
- Hemispheric Asymmetry in Neuroscience
- Type
- article
- Field-Weighted Citation Impact
- 1.37
Funders
- LivaNova
- Australian Government
- Eisai
- Sun Pharma
- UCB Pharma