Impact of lifetime antiepileptic drug history on cenobamate efficacy in adults with focal epilepsy
This study highlights greater efficacy of CNB in patients with <6 lifetime ASMs, showing a significantly higher seizure-free rate and greater seizure reduction compared to those with >10 lifetime ASMs. Despite lower overall response in the latter group, CNB treatment still provided meaningful benefits in highly drug-resistant epilepsy.
Authors
- Martin Hirsch (ORCID: https://orcid.org/0000-0002-0192-2803)
- Armin Brandt (ORCID: https://orcid.org/0000-0001-5217-0325)
- Eva Martinez‐Lizana (ORCID: https://orcid.org/0000-0001-7653-9449)
- Yulia Novitskaya (ORCID: https://orcid.org/0000-0002-0905-9936)
- Andreas Schulze‐Bonhage (ORCID: https://orcid.org/0000-0003-2382-0506)
Institutions
- University Medical Center Freiburg (DE)
Publication Details
- Journal
- Seizure
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.seizure.2024.12.010
- Citations
- 5
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- European Commission