Generation of induced pluripotent stem cell line, NCHi027-A, from a female child with Posterior Cloaca (Type B)

Cloaca is an ultra-rare severe anorectal malformation in females where the gastrointestinal, genital, and urologic systems converge. Posterior Cloaca (Type B) is an extremely rare specific variant, where the urogenital sinus opens just anterior to the anus. NCHi027-A is an iPSC line derived from skin fibroblasts of a 4 year and 8-month-old female with Posterior Cloaca (Type B) using Sendai Virus reprogramming. This iPSC line shows typical iPSC morphology, has normal karyotype, expresses pluripotency markers, and can be differentiated into three germ layers.

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Publication Details

Journal
Stem Cell Research
Published
2024-12-20
DOI
https://doi.org/10.1016/j.scr.2024.103636
Primary Topic
Congenital gastrointestinal and neural anomalies
Type
article
Field-Weighted Citation Impact
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article

Generation of induced pluripotent stem cell line, NCHi027-A, from a female child with Posterior Cloaca (Type B)

Linda A. Baker, Cintia Elisabeth Gomez Limia, Karunya Albert, Nathália G. Amado et al.
Stem Cell Research
Congenital gastrointestinal and neural anomalies
article

Generation of induced pluripotent stem cell line, NCHi027-A, from a female child with Posterior Cloaca (Type B)

Linda A. Baker, Cintia Elisabeth Gomez Limia, Karunya Albert, Nathália G. Amado, Kumar Basnet, Chaitrali Atre, Darria L Streeter
article en

Abstract

Cloaca is an ultra-rare severe anorectal malformation in females where the gastrointestinal, genital, and urologic systems converge. Posterior Cloaca (Type B) is an extremely rare specific variant, where the urogenital sinus opens just anterior to the anus. NCHi027-A is an iPSC line derived from skin fibroblasts of a 4 year and 8-month-old female with Posterior Cloaca (Type B) using Sendai Virus reprogramming. This iPSC line shows typical iPSC morphology, has normal karyotype, expresses pluripotency markers, and can be differentiated into three germ layers.

Stem Cell ResearchVol. 82
Nationwide Children's Hospital (US)
Gender equality
Openalex Percentile: Top 56%
Congenital gastrointestinal and neural anomalies
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