Exploring the neuropsychiatric consequences of methionine exposure: Behavioral and cognitive alterations in zebrafish models

Methionine (Met) is an essential amino acid vital in numerous biological processes. Because it plays a crucial role in protein synthesis and metabolism, it has attracted attention for its diverse physiological roles and potential toxicological implications. This amino acid cannot be synthesized de novo by humans, so it must be obtained through diet or supplements. Despite its essentiality, excessive methionine intake has been associated with adverse effects on various organisms, raising concerns about potential toxicity. The purpose of this article is to review the literature on the impact of Met exposure across multiple model organisms, including humans, rodents, and zebrafish. Also, this article analyzes the effects of exposure to two concentrations of methionine (1.5 mM and 3 mM) on zebrafish, focusing on behavior and decision-making power after administration. Concentrations, administration, and observed effects are also summarized, highlighting the relevance of zebrafish as a model for studying methionine toxicity.