HPV Independent, Gastric Type Adenocarcinoma of Cervix - Case Report of a Rare Aggressive Subtype

Adenocarcinoma of cervix, HPV independent, gastric type is an invasive adenocarcinoma showing gastric (pyloric) differentiation, unrelated to HPV infection. The patients present with highly atypical clinical features and exhibits aggressive biological behaviour, making timely diagnosis particularly challenging. In the present study, we report a case of a 46 year old female who presented with increased vaginal discharge. Vaginal vault mass excision was done. Histopathology and IHC favoured a diagnosis of Adenocarcinoma of cervix, HPV independent, Gastric type.