Heterogeneous Cardiac-Derived and Neural Crest–Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption
There are multiple subtypes of cardiac-derived and neural crest-derived SMCs with shared or distinctive transcriptional profiles; neural crest subset cluster SMCs with increased expression of certain TGFβ-inducible genes are not spatially linked to the aortic root predisposed to aneurysms from aberrant TGFβ signaling; and loss of TGFβ responses after receptor deletion is uniform among SMC clusters.
Authors
- Roland Assi (ORCID: https://orcid.org/0000-0002-0863-9867)
- George Tellides (ORCID: https://orcid.org/0000-0001-7042-8190)
- Abdulrahman Hassab (ORCID: https://orcid.org/0009-0005-0722-6007)
- LI Guangxin (ORCID: https://orcid.org/0000-0001-5620-0691)
- Bo Jiang
- Pengwei Ren (ORCID: https://orcid.org/0000-0003-2853-412X)
- Wei Li (ORCID: https://orcid.org/0000-0002-2035-0134)
Institutions
- Peking University (CN)
- Yale University (US)
- VA Connecticut Healthcare System (US)
- Peking University People's Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1161/atvbaha.124.321706
- Citations
- 6
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 3.30