Clinical Application of Metagenomic Next-Generation Sequencing (mNGS) in Patients with Early Pulmonary Infection After Liver Transplantation
mNGS offers rapid detection, a high positivity rate, insensitivity to antibiotics, and a superior ability to detect mixed infections in patients with early post-transplant pulmonary infections. Additionally, mNGS shows good consistency with traditional culture and can predict drug-resistant phenotypes to guide targeted antibiotic therapy for early-stage post-transplant pulmonary infection after liver transplantation. Patients whose antibiotic therapy is based on mNGS results have experienced decreased mortality rates and overall improved prognosis.
Authors
- Haofeng Xiong (ORCID: https://orcid.org/0000-0002-3213-4041)
- Shuang Zhao (ORCID: https://orcid.org/0000-0001-7081-6177)
- Zhiying He (ORCID: https://orcid.org/0000-0002-0087-2277)
- Jingyi Liu (ORCID: https://orcid.org/0000-0001-7123-0119)
- Yizhi Zhang (ORCID: https://orcid.org/0009-0000-5586-5886)
- Li-Ying Sun
- Fei Hou (ORCID: https://orcid.org/0000-0002-3512-5589)
- Hongli Peng
- Ying Liu (ORCID: https://orcid.org/0000-0002-7164-962X)
Institutions
- Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/idr.s483684
- Citations
- 2
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Capital Medical University
- Beijing Friendship Hospital, Capital Medical University