Landscape of somatic mutations and clonal evolution in <i>NUP98</i>‐rearranged adult acute myeloid leukaemia
Acute myeloid leukaemia with NUP98 rearrangement (AML-NUP98) has been previously described in paediatric patients, and the clinical significance in adult AML patients remains largely unexplored. In this study, we identified specific partner fusion genes and examined somatic co-mutations and clonal evolution longitudinally in adult AML-NUP98 patients. Our comprehensive analysis provides an understanding of NUP98 rearrangement and co-mutations influencing clonal evolution and disease progression and offers valuable insights into potential therapeutic strategies. Further multiple centre studies are needed to investigate this entity in adult patients and improve treatment strategy.
Authors
- Candace Frerich
- Ronan Swords (ORCID: https://orcid.org/0000-0003-3319-1870)
- Philipp W. Raess (ORCID: https://orcid.org/0000-0002-6841-4993)
- Joanna Wiszniewska (ORCID: https://orcid.org/0000-0003-2970-8005)
- Nicola Long (ORCID: https://orcid.org/0000-0002-9010-8167)
- Richard D. Press (ORCID: https://orcid.org/0000-0002-2103-5144)
- Wei Xie (ORCID: https://orcid.org/0000-0003-1815-7666)
- Jose Solis‐Ruiz (ORCID: https://orcid.org/0000-0002-9867-6265)
- Curtis A. Lachowiez (ORCID: https://orcid.org/0000-0001-8506-0624)
- Peng Li (ORCID: https://orcid.org/0000-0003-4711-362X)
- Guang Fan
- Jennifer Dunlap (ORCID: https://orcid.org/0000-0002-6399-6592)
Institutions
- Oregon Health & Science University (US)
- University of Utah (US)
Publication Details
- Journal
- British Journal of Haematology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1111/bjh.19962
- Citations
- 3
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.36