Compression force promotes the osteogenic differentiation of periodontal ligament stem cells by regulating NAT10-mediated ac4C modification of BMP2
This study demonstrated that compressive force promotes cell viability and osteogenic differentiation of PDLSCs by regulating BMP2 levels mediated by NAT10. NAT10 mediated ac4C levels of BMP2 is the key signaling axis of orthodontic stress in promoting cell growth and osteogenic differentiation of PDLSCs.
Authors
- Yan Feng (ORCID: https://orcid.org/0000-0002-3906-6539)
- Ting Zhang (ORCID: https://orcid.org/0009-0005-2778-7610)
- Yue Chang
Institutions
- Xuzhou Medical College (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s13018-024-05302-w
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.94