Sex-Differences Influence Depressive-Like Behaviour via Alterations in Microglial Expression of GIF-1, TREM2, and IL-1β in an Acute Lipopolysaccharide-Induced Murine Neuroinflammation Model
This study revealed that LPS-induced sex-specific changes in genes involved in neuronal cell survival caused behavioural alterations in male mice. Moreover, females had observed inflammatory responses that had no impact on behavioural alterations. Overall, both sexes exhibited sex-specific microglial activation states.
Authors
- Fadwa M. Alkhulaifi (ORCID: https://orcid.org/0000-0003-2213-7174)
- Suliman Yousef Alomar (ORCID: https://orcid.org/0000-0002-2864-1649)
- Rasha Alonaizan (ORCID: https://orcid.org/0009-0005-7312-309X)
- Wedad H. Alotaibi
- Ashwaq Alsulami
Institutions
- King Saud University (SA)
- Imam Abdulrahman Bin Faisal University (SA)
Publication Details
- Journal
- Immunological Investigations
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1080/08820139.2024.2440006
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- King Saud University