Metformin protects prepubertal mice ovarian reserve against cyclophosphamide via regulation of the PI3K/Akt/mTOR signaling pathway and Yap-1
Our results advocate for the potential of metformin as a viable therapeutic option for preserving ovarian function in cyclophosphamide-treated adolescent girls, given its favorable side effect profile and ability to improve cyclophosphamide-induced ovarian damage.
Authors
- Azam Dalman (ORCID: https://orcid.org/0000-0002-5891-3094)
- Hamid Gourabi (ORCID: https://orcid.org/0000-0001-7277-4898)
- Maryam Hezavehei (ORCID: https://orcid.org/0000-0003-1460-1862)
- Parvaneh Afsharian (ORCID: https://orcid.org/0000-0003-2249-7137)
- Negin Zatalian
Institutions
- University of Science and Culture (IR)
- Royan Institute (IR)
- Academic Center for Education, Culture and Research (IR)
- Cegep de Saint Hyacinthe (CA)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s13048-024-01572-4
- Citations
- 8
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 4.34
Funders
- Royan Institute