Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases
Collectively, the current study discoveries the antimicrobial agent CQ as a potentially specific NLRP3 inhibitor, and its use provides a feasible therapeutic approach for the treatment of NLRP3-driven diseases.
Authors
- Qin Sun (ORCID: https://orcid.org/0009-0004-9306-2055)
- Hongping Shen (ORCID: https://orcid.org/0009-0006-5736-6427)
- Wenhao Liao (ORCID: https://orcid.org/0000-0002-6986-8663)
- Menglin Yao
- Yuchen Li (ORCID: https://orcid.org/0000-0002-1594-2717)
- Ting Wang (ORCID: https://orcid.org/0000-0003-0667-6709)
- Jingwen Liu (ORCID: https://orcid.org/0000-0003-4686-1175)
- Zhilei Wang (ORCID: https://orcid.org/0000-0001-5518-954X)
- Yu Mou (ORCID: https://orcid.org/0009-0008-6323-0328)
- Jianyuan Tang
Institutions
- Southwest Medical University (CN)
- Second Affiliated Hospital of Chengdu University of Traditional Chinese (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s10020-024-01016-1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Sichuan Provincial Key Laboratory of Shock and Vibration of Engineering Materials and Structures, Southwest University of Science and Technology
- Luzhou Science and Technology Bureau
- Postdoctoral Research Foundation of China