Topical Adipose Mesenchymal Stem Cell Secretome Cream Improves Wound Healing in Partial-Thickness Burned Mice

Burn injury has a high prevalence worldwide; it is estimated that there were nearly 9 million burn cases in 2019. This injury impacts the physical and mental well-being of the patient, as well as their overall quality of life. This study aims to analyze the therapeutical effect of Mesenchymal Stem Cells Secretome (MSCS) for partial-thickness burn wounds. This research is experimental research with a Posttest-Only Control Group Design. The sample consisted of 24 white mice divided into three groups: the control group, the 1% silver sulfadiazine (SSD) group and the MSCS group. A histopathological examination of the wound was performed by hematoxylin-eosin staining. The average thickness measurement of the burn surface epidermis in the SSD and MSCS treatment groups showed a thicker epidermis than the control group. The vascular density in the granulation tissue of the SSD (35.63) and MSCS (34.00) treatment groups decreased compared to the control group. The fibroblast density in the granulation tissue of the SSD (66.75) and MSCS (70.25) treatment groups was reduced compared to that of the control group. The inflammatory cell density in the granulation tissue of the SSD (70.75) and MSCS (50.88) treatment groups decreased than the control group. The administration of MSCS cream showed a better histopathological image than the control and was comparable to SSD treatment groups.