A meta-analysis study: Vitamin D receptor genetic polymorphism in Respiratory tuberculosis

Our study performed meta-analysis of all available literature on numerous features of relation concerning vitamin D genetic polymorphisms and pulmonary tuberculosis. PubMed and Springer databases were hunted and out of 365 articles, 40 studies were chosen for the present review to examine the relation of PTB with vitamin D receptors (VDR). A total of 18637 patients and 25515 controls, with 35 investigations on VDR FokI polymorphism, 33 on VDR TaqI polymorphism, 25 on VDR BsmI polymorphism and 22 on VDR ApaI polymorphism were included. To understand the connection of polymorphisms with Tuberculosis (TB) hazard, the odds ratios (ORs) and the conforming 95% confidence intervals (CIs) were estimated rendering to the occurrences of genotypes. P values of 0.05 were considered statistically relevant. Funnel maps were used to evaluate publication bias. Several published articles observed the relation of FokI, ApaI, BsmI and TaqI gene polymorphism of VDR with pulmonary tuberculosis (PTB). Their outcomes were unpredictable; hence we did a meta-analysis to find the precise relativeness of the four. Our findings complement many studies being conducted on various communities across the world to better understand the significance of VDR polymorphism in PTB. FokI, TaqI and ApaI showed risk and TaqI showed no risk of PTB development in the population. Depleted amounts of vitamin D were seen in TB patients. Our analysis exposed the relation between vitamin D receptor gene polymorphism and TB. This meta-analysis shows that VDR FokI polymorphism pays to the hazard of pulmonary TB.