Electrochemical Desaturation and β-Thiocyanation of Cyclic Amides
The site-selective functionalization of cyclic amides provides an attractive protocol for the synthesis of valuable molecules. We report herein an electrochemical desaturation and β-thiocyanation of cyclic amides under external oxidant-free conditions. This method exhibits broad functional group tolerance, excellent selectivity, mild reaction conditions and can be applied for late-stage functionalization of bioactive molecules. Mechanistic studies indicate that an enamide intermediate might be involved.
Authors
- Li‐Rong Wen (ORCID: https://orcid.org/0000-0001-7976-0878)
- Lin‐Bao Zhang (ORCID: https://orcid.org/0000-0002-8334-4188)
- Weisi Guo (ORCID: https://orcid.org/0000-0001-6688-4679)
- Jin Zhang (ORCID: https://orcid.org/0000-0002-4102-1866)
- Kaili Miao
- Ming Li (ORCID: https://orcid.org/0000-0003-4906-936X)
- Jiaxin Chen (ORCID: https://orcid.org/0009-0003-5056-2634)
Institutions
- Qingdao University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1021/acs.orglett.4c04141
- Citations
- 8
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Natural Science Foundation of Shandong Province
- Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China