Genome-wide DNA methylation and gene expression in human placentas derived from assisted reproductive technology
Decreased expressions of TRIM28, NOTCH3, and DLK1 bring forth potential mechanisms for several phenotypic features associated with ART. Our results support previous procedure specific findings: the changes associated with growth and metabolism link more prominently to the fresh embryo transfer with smaller placentas and newborns, than to the frozen embryo transfer with larger placentas and newborns. Furthermore, since the observed changes associate also with subfertility, they offer a precious insight to the molecular background of infertility.
Authors
- E. Wallén (ORCID: https://orcid.org/0000-0002-9926-0106)
- Christel Hydén‐Granskog (ORCID: https://orcid.org/0000-0002-0209-0121)
- Aila Tiitinen (ORCID: https://orcid.org/0000-0003-3088-5594)
- K. Rämö (ORCID: https://orcid.org/0000-0001-8070-4785)
- Heidi Marjonen (ORCID: https://orcid.org/0000-0001-5595-9946)
- Juho Vehviläinen (ORCID: https://orcid.org/0000-0001-7521-8512)
- Viveca Söderström‐Anttila (ORCID: https://orcid.org/0000-0002-3577-0860)
- Timo Tuuri (ORCID: https://orcid.org/0000-0003-0734-3244)
- Hanna Kahila (ORCID: https://orcid.org/0000-0001-9658-1193)
- Nina Kaminen‐Ahola (ORCID: https://orcid.org/0000-0003-1255-4716)
- Pauliina Auvinen (ORCID: https://orcid.org/0000-0001-7865-0482)
- Ida Laukkanen
Institutions
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- Väestöliitto (FI)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1038/s43856-024-00694-6
- Citations
- 6
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 3.30
Funders
- Helsingin Yliopisto
- Suomen Kulttuurirahasto