Radiotherapy‐resistant prostate cancer cells escape immune checkpoint blockade through the senescence‐related ataxia telangiectasia and Rad3‐related protein
Our findings indicate that the activation of cytosolic ATR, which is associated with cellular senescence, impedes the effectiveness of combined RT and ICB treatments. This discovery may provide valuable insights for improving the efficacy of combined RT and ICB therapies in PCa.
Authors
- Simeng Wen (ORCID: https://orcid.org/0000-0001-7989-7700)
- Chenyi Shao
- Jiajia Chen (ORCID: https://orcid.org/0000-0002-2068-509X)
- Hang Li (ORCID: https://orcid.org/0000-0003-4905-2242)
- Saijun Fan (ORCID: https://orcid.org/0000-0003-0691-6864)
- Yingyi Zhang (ORCID: https://orcid.org/0000-0003-1020-7964)
- Yu Zhao (ORCID: https://orcid.org/0000-0002-1242-2257)
- Ting Huang (ORCID: https://orcid.org/0000-0001-6695-4972)
- Sen Wang (ORCID: https://orcid.org/0009-0005-2988-4510)
Institutions
- Mayo Clinic (US)
- Tianjin University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- WinnMed (US)
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1002/cac2.12636
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- National Natural Science Foundation of China