Discovery of Novel Antimalarial Agents: In vitro Biological Evaluation of a Series of Rhodanine Analogues

Discovery of novel antimalarial agents is in urgent demand due to the global emergence of Plasmodium falciparum resistant malaria against first-line drugs. In line with the demand, we studied in vitro antimalarial properties of a series of rhodanine analogues (C-C13) for their bioactive potential against P falciparum. Based on the analysis of screening results and structure-activity relationship (SAR), C11 was found to be a promising bioactive hit molecule (IC50: 4.755 μM).