Evolution of Eligibility Criteria in Inflammatory Bowel Disease Clinical Trials: A Clinical Trial Databank Analysis
The median number of eligibility criteria for IBD RCTs did not significantly change over time. The eligibility criteria are however restrictive and complex, limiting the generalisability of efficacy and safety outcomes in daily practice when drugs are approved. Future research is needed to investigate the impact of broadening eligibility criteria to better encompass real-world practice.
Authors
- Liese Barbier (ORCID: https://orcid.org/0000-0003-1786-2080)
- Severine A.R.A. Vermeire (ORCID: https://orcid.org/0000-0001-9942-3019)
- Bram Verstockt (ORCID: https://orcid.org/0000-0003-3898-7093)
- An Outtier (ORCID: https://orcid.org/0000-0002-7351-0023)
- Rosanne Janssens (ORCID: https://orcid.org/0000-0003-1982-4176)
- João Sabino (ORCID: https://orcid.org/0000-0002-8892-7075)
- Isabelle Huys (ORCID: https://orcid.org/0000-0002-4738-8298)
- Marc Ferrante
Institutions
- KU Leuven (BE)
Publication Details
- Journal
- United European Gastroenterology Journal
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1002/ueg2.12731
- Citations
- 4
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.20
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering